#Surgery negative pressure wound therapy trial#
This was a superiority, open-label, randomized controlled trial with two parallel intervention arms. The aim of this randomized controlled trial was to assess the effectiveness of the prophylactic use of NPWT in reducing the rate of incisional SSIs and wound complications after stoma reversal in colorectal surgery performed for both oncological and benign indications, investigating unexplored outcomes, including pain and cosmetic satisfaction. Moreover, these trials failed to assess important patient-related outcomes, such as pain, aesthetic satisfaction and quality of life. Previous randomized studies were focused on patients with either inflammatory bowel disease or cancer, and led to conflicting results 16, 17. Single-use negative-pressure wound therapy (NPWT) may represent a strategy to reduce the SSI rate while shortening healing times compared with conventional wound dressing. Wound closure with a purse-string suture (PSS) provides lower rates of incisional SSI compared with direct closure 10–13 however, it requires longer healing times 10, 14 and often results in a cosmetically poor scar that leaves the patient dissatisfied 15. Patient-related factors, such as smoking 5, obesity 6 or preoperative immunomodulating therapies 7, and surgery-related factors, such as wound-closure techniques 8, 9, are known risk factors for the occurrence of incisional SSIs and wound-related complications. Stoma reversal in colorectal surgery is associated with high postoperative morbidity, with reported rates up to 33 per cent 1–4, including wound complications and surgical-site infections (SSIs).
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